Archives

  • 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2020-03
  • 2020-07
  • 2020-08
  • br opioid abuse in an important subpopulation of cancer

    2020-08-06


    opioid abuse in an important subpopulation of cancer patients.
    In conclusion, our assessment of the impact of long-term NSAID use on select health outcome indices among women with breast cancer showed that long-term NSAID use was associated with lower opioid abuse, lower inpatient mortality and reduced hospital LOS. In addition to addressing existing knowledge gaps, this study also lends to the limited body of evidence on the role of NSAIDs in the management of cancer pain. We hope this study will contribute to management guidelines as well as policies aimed at addressing the epidemic of opioid abuse in the US.
    Declarations of interest
    The authors declare no conflict of interest.
    Funding
    This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
    Supplementary materials
    References
    [21] L.B. Ready, C.R. Brown, L.H. Stahlgren, et al., Evaluation of intravenous ketorolac administered by ABT-263 (Navitoclax) or infusion for treatment of postoperative pain. A double-blind, placebo-controlled, multicenter study, Anesthesiology 80 (6) (1994) 1277–1286.
    5 Accepted Manuscript
    Association between Nicotine-Dependent Gene Polymorphism and Smoking Cessation in Patients with Lung Cancer
    Fen Gu, Chao Zhao, Tao Jiang, Xuefei Li, Yanjun Mao, Caicun Zhou
    To appear in: Clinical Lung Cancer
    This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    ACCEPTED MANUSCRIPT
    Association between Nicotine-Dependent Gene Polymorphism and Smoking Cessation in Patients with Lung Cancer
    Fen Gu1, 3, Chao Zhao1, 3, Tao Jiang1, Xuefei Li1, Yanjun Mao2,4, Caicun Zhou1,4 1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China
    2 Nursing Department, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China 3 Fen Gu & Chao Zhao contributed equally to the article.
    4 Correspondence to:
    Running title: Nicotine-dependent gene polymorphism in lung cancer
    Conflict of interest: The authors declared no potential conflict of interest.
    Funding statement: The study was supported by the Eagle Plan of Shanghai Pulmonary Hospital (No. HR2016001). Abstract
    Background: Patients with lung cancer continue to smoke due to complex factors. Failure to quit smoking (defined as nicotine dependence) is significantly associated with genetic status. This study aimed to investigate the relationship between polymorphisms in nicotine dependence genes and smoking status after the diagnosis of lung cancer. Patients and Methods: A total of 240 patients with lung cancer were included from July 2017 to March 2018. According to the actual smoking condition after lung cancer diagnosis, eligible patients were divided into three groups: never smoking group, failure to quit smoking group and successful smoking cessation group. FTND scores were used to evaluate the smoking status of each group. Three nicotine-dependent genes with six loci were detected. Results: Among the 240 patients, 86 were never smokers, 51 failed to quit smoking, and 104 successfully quit smoking. The initial age of smoking in the failure to quit smoking group was significantly younger than those in the successful smoking cessation group (P = 0.001). There was a significant difference in the GG and AG and AA genotype distributions of CHRNA3 (rs578776) among the three groups (P = 0.003). There was also a significant difference in the distribution of CHRNA4 (rs2229959) genotypes among the three groups (P = 0.003). However, there was no significant difference in the genotype distribution of CHRNA5 (rs588765) among the three groups (P = 0.277).
    ACCEPTED MANUSCRIPT
    cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer. Key words: lung cancer, smoking, nicotine dependence, gene polymorphism
    ACCEPTED MANUSCRIPT
    Introduction
    Smoking is one of the independent risk factors of lung cancer. Smoking cessation is of great clinical significance for the prevention and treatment of lung cancer. Previous studies have reported that a high proportion (range 26.6 to 50.0%) of patients with smoking history would continue to smoke after diagnosis of lung cancer1, 2, suggesting that smoking continuation after the diagnosis of lung cancer remains a critical issue in the management of lung cancer patients.