• If the cell and the SR

  2019-07-24

  

  If the cell and the SR are overloaded with Ca2+ then abnormal Ca2+ transients (Fig. 4A) and spontaneous Ca2+ waves (Fig. 4B) are expected to appear [63]. A high occurrence of Ca2+ sparks, fueling SR Ca2+ leak and cytosolic Ca2+ overload, was an unexpected early signature in our model. Late SR Ca2+ l

• The following are the supplementary

  2019-07-24

  

  The following are the supplementary data related to this article. Conflicts of interest statement Transparency document Acknowledgements This research was supported by Grants from University of Basilicata to VI (grant number 3010101), University of Bari to VI (grant number 00405815), and b

• br Materials and methods br Results

  2019-07-24

  

  Materials and methods Results Discussion We present an updated version of Recon 2.2 that was curated and extended to correctly represent the flavoprotein-catalysed reactions. Furthermore, we introduced a new method to study the role of enzyme-bound cofactors, such as FAD. Curating the repre

• Osteoclasts on attachment to bone surface or

  2019-07-11

  

  Osteoclasts on attachment to bone surface or culture vessel reorganize their Nifurtimox cytoskeleton to form a sealing zone, wherein they create an acidic environment and secrete bone resorbing enzymes. They also form integrin-based and F-actin rich unique cell adhesion structures called podosomes

• Such analysis of mitochondrial function expected to be very

  2019-07-11

  

  Such analysis of mitochondrial function expected to be very important in septic patients. Mervyn Singer and his group review the current knowledge [] on the role of mitochondria in sepsis. Mitochondrial dysfunction has been suggested as a discriminator between survival and death. Importantly, an ear

• br Modeling of genetic and complex

  2019-07-08

  

  Modeling of genetic and complex liver diseases iPSCs can be generated directly from patients with specific diseases and their differentiation program allows to recapitulate in vitro the progression of the disease, thus making them an ideal tool to model liver diseases, better if genetic. Several

• br Conclusion The following is the supplementary data relate

  2019-07-08

  

  Conclusion The following is the supplementary data related to this article. Conflict of interest Substantial author contributions Andreina Bruno: to the conception and design of the study, to the acquisition, the interpretation and the analysis of data and to write the manuscript; Caterin

• The expression of LRP was

  2019-07-08

  

  The expression of LRP1 was found to be sensitive to several factors thought to mediate the pathogenesis of PH. For example, hypoxia-inducible factor-1α (HIF1α) was reported to drive LRP1 expression in vascular SMC cultured under hypoxic conditions [26]. Furthermore, angiotensin II, a peptide hormone

• Besides its association with tumor angiogenesis EBER

  2019-07-08

  

  Besides its association with tumor angiogenesis, EBER-mediated VCAM-1 expression might contribute to tumor progression in various ways. The last few years have witnessed an ever-increasing body of knowledge on the molecular understanding of tumorigenicity and metastasis, and an impressive variety of

• PTMs characterize some of the most discussed players amyloid

  2019-07-05

  

  PTMs characterize some of the most discussed players (amyloid-beta, α-synuclein, tau, etc.) in neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD) [1,7,8]. Because of the ways in which PTMs can so drastically alter the functions of proteins, they are strictly c

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